I have used several different cartridges with it, and never have any difficulty loading them. Some of the cartridges that I've used: a matte laminate/adhesive back to make home decor scrapbook projects (now the items can be cleaned w/o worry about damaging the pictures), the laminate/magnet for pictures that my husband can put on his metal cabinets at work, double laminate to protect items for my kids so they can touch them. I couldn't be without this machine!